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Serial vaccination Rather than trying to present multiple antigens together in the form of a mosaic vaccine to the immune system, an alternative approach could be to sequentially vaccinate with different antigens in a series in an attempt to boost the most cross-reactive immunity (Fig

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There are significant differences in the neurotoxic target sites, clinical phenotypes, and accumulation potential of different platinum-based agents, among which oxaliplatin-mediated peripheral sensory neuropathy and cisplatin-mediated irreversible ototoxicity are the most typical

doi: 10.1186/s13063-021-05242-4